Shopping Cart

Remove All
Your shopping cart is currently empty

Sumanirole maleate

Name: Sumanirole maleate
Brand: TargetMol
SKU: TQ0140
Price: 69 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. TQ0140Cas No. 179386-44-8

Alias U-95666E, U95666E, PNU-95666, PNU95666

Sumanirole maleate (PNU-95666E) is a D2 receptor full agonist with high selectivity (ED50 = 46 nM) that improves motor function in patients with Parkinson's disease and plays an important role in the study of restless legs syndrome.

Sumanirole maleate

🥰Excellent

Catalog No. TQ0140Alias U-95666E, U95666E, PNU-95666, PNU95666Cas No. 179386-44-8

Pack Size	Price	Availability	Quantity
2 mg	$69	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Resource Download

COA

Product Introduction

Bioactivity

Description	Sumanirole maleate (PNU-95666E) is a D2 receptor full agonist with high selectivity (ED50 = 46 nM) that improves motor function in patients with Parkinson's disease and plays an important role in the study of restless legs syndrome.
Targets&IC50	D2 receptor:46 nM (EC50)
Synonyms	U-95666E, U95666E, PNU-95666, PNU95666

Chemical Properties

Molecular Weight	319.31
Formula	C₁₅H₁₇N₃O₅
Cas No.	179386-44-8
Smiles	C(=C\C(O)=O)\C(O)=O.O=C1N2C3=C(C[C@@H](NC)C2)C=CC=C3N1
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (125.27 mM), Sonication is recommended.

H2O: 8 mg/mL (25.05 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1318 mL	15.6588 mL	31.3175 mL	156.5876 mL
5 mM	0.6264 mL	3.1318 mL	6.2635 mL	31.3175 mL
10 mM	0.3132 mL	1.5659 mL	3.1318 mL	15.6588 mL
20 mM	0.1566 mL	0.7829 mL	1.5659 mL	7.8294 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0626 mL	0.3132 mL	0.6264 mL	3.1318 mL
100 mM	0.0313 mL	0.1566 mL	0.3132 mL	1.5659 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc